Our Technology
SiSafe® - Our Platform Technology
Even when using new ingredients, conventional formulas still fall short of delivering significant results. The reason is simple: the problem is not the active compound itself but its delivery to the target site. Since the stratum corneum prevents easy penetration of large molecules and hydrophobic compounds, only a limited amount of the ingredients in conventional formulas is able to enter into the skin and reach the deeper layers.
In contrast, SiSafe uses nanosilicon as a carrier for active compounds allowing them to penetrate deep beneath the skin's epidermal barrier for controlled release. With our proprietary formula, we are able to increase the solubility of active compounds, thus enhancing their bioavailability.
SiSafe is game changing technology.
SiSaf's nanoparticles dissolve to orthosilicic acid, the natural form of silicon absorbed from food. Orthosilicic acid has a positive safety and toxicological profile – it's literally edible.
Bioactive Delivery
Unlike any other delivery technology, SiSafe is a bioactive delivery system, in which the carrier itself is an active compound with beneficial dermatological properties.
Solubility
An estimated 60% of new chemical entities (NCEs) discovered by the pharmaceutical industry today, as well as many existing drugs, are poorly soluble or lipophilic compounds. The solubility issues severely restrict the delivery of many existing drugs. SiSafe significantly improves the solubility of compounds thus enhancing their bioavailability.
Stability
SiSafe can considerably increase the stability of compounds.
Skin penetration
SiSafe allows active compounds to penetrate the skin's epidermal barrier for controlled release in the deeper skin layers.
Controlled release
SiSafe's release profile can be customised to fit our clients' specific requirements.
Localization
SiSafe prevents systemic absorption of the active compound.
