SiSaf believes that medicines should be developed on the basis of how they help people rather than how they solve a formulation problem. SiSaf is a world leading expert in nanoparticle silicon technology and has developed a next generation drug delivery platform called SiSafe.®
Our mission is to enhance new and existing medicines in ways not possible before so that more people can benefit more easily from the science and research of the world’s leading scientists.
The platform has a wide variety of formulation applications but is particularly suited to solving the most complex bioavailability challenges:
SiSafe® is patented elemental nano-silicon with a porous structure and massive surface area.
Molecules are incorporated within the nanopores which stabilizes unstable molecules and provides very significant increases in the bioavailability of even the most hydrophobic compounds.
SiSafe® is biodegradable and the kinetics of drug release depend on the rate of biodegradation of the matrix. The rate of onset and release can be customized by altering physical factors of the carrier including particle size, porosity, linkage method and pore width.
SiSafe® has very high drug-loading capacity (requiring low ratio of carrier) compared with other drug carriers.
Biocompatible SiSafe® fully dissolves to orthosilicic acid, the natural form of silicon absorbed from food. Orthosilicic acid has a positive safety and toxicological profile – it's literally edible.
These particles, each 100 times smaller than a human hair, contain microscopic reservoirs that can hold and protect sensitive drugs.
SiSafe® is fully patented but also requires specific trade-secret know-how to produce. And because it cannot be reverse engineered “patent” protection is highly sustainable
SiSaf has a world class multi-disciplinary team of drug delivery experts, immunology and formulation scientists. They provide a range of services to transform complex formulation challenges into better medicines with an enriched therapeutic profile.
From site specific transfection of tiny siRNA for gene therapy to oral delivery of large unstable peptides and proteins – the team helps in every stage of the process.
SiSaf can tailor a bespoke package of formulation products and consultancy services. Please contact us for more information.
Transform a modest injectable to a blockbuster oral or transdermal format.
If you would like to know more about our technology platform, our products or simply how we can best support your business development, then please forward us some basic details.